{"schema_version":"1.0","hypothesis_id":1616,"triple":{"drug":"Isochaihulactone","drug_canonical":"isochaihulactone","mediator":"EGFR","mediator_canonical":"EGFR","outcome":"pancreatic ductal adenocarcinoma","outcome_canonical":"pancreatic ductal adenocarcinoma"},"domain":{"domain":"cross_domain","source":"glioblastoma","target":"pancreatic_cancer"},"provenance_completeness":"partial_backfill","completeness_notes":"Backfilled retroactively from DB state on 2026-05-13. The pipeline_run this row references was created by the backfill script, not by the actual generation orchestrator. Source papers, claims, scoring, and embedding config are recovered; generation-time metadata (exact git commit at gen time, host, exact command) is not recoverable.","source_papers":[{"doi":"10.1002/advs.202414982","pmid":"40130819","year":2025,"roles":["mediator_outcome"],"title":"Identification of Tumor‐Specific Surface Proteins Enables Quantification of Extracellular Vesicle Subtypes for Early Detection of Pancreatic Ductal Adenocarcinoma","journal":"Adv Sci (Weinh)","work_id":73301,"publication_date":"2025-03-25"},{"doi":"10.1016/j.heliyon.2024.e40744","pmid":"39720087","year":2024,"roles":["drug_mediator"],"title":"Integrative bioinformatic analysis to identify potential phytochemical candidates for glioblastoma","journal":"Heliyon","work_id":8134,"publication_date":"2024-12-01"},{"doi":"10.1021/acs.bioconjchem.9b00632","pmid":"31584260","year":2019,"roles":["mediator_outcome"],"title":"Design and Evaluation of PEGylated Liposomal Formulation of a Novel Multikinase Inhibitor for Enhanced Chemosensitivity and Inhibition of Metastatic Pancreatic Ductal Adenocarcinoma","journal":"Bioconjug Chem","work_id":175523,"publication_date":"2019-10-04"},{"doi":null,"pmid":"26339400","year":2015,"roles":["mediator_outcome"],"title":"EGFR expression in pancreatic intraepithelial neoplasia and ductal adenocarcinoma.","journal":"Int J Clin Exp Pathol","work_id":75219,"publication_date":"2015-01-01"}],"source_paper_count":4,"extracted_claims":[{"side":"drug_mediator","object":"EGFR","context":"molecular docking simulation","subject":"Isochaihulactone","work_id":8134,"claim_id":9015,"polarity":"positive","predicate":"binds_to","confidence":0.8,"extraction_run_id":9},{"side":"mediator_outcome","object":"pancreatic ductal adenocarcinoma","context":"PDAC-derived extracellular vesicles","subject":"EGFR","work_id":73301,"claim_id":67699,"polarity":"positive","predicate":"associated_with","confidence":0.95,"extraction_run_id":17},{"side":"mediator_outcome","object":"pancreatic ductal adenocarcinoma","context":"in tissue microarray of 81 PDA cases","subject":"EGFR","work_id":75219,"claim_id":73030,"polarity":"positive","predicate":"associated_with","confidence":0.95,"extraction_run_id":17},{"side":"mediator_outcome","object":"pancreatic ductal adenocarcinoma","context":"in PDAC","subject":"EGFR","work_id":175523,"claim_id":130008,"polarity":"positive","predicate":"associated_with","confidence":0.9,"extraction_run_id":23}],"extracted_claim_count":4,"extraction":{"model":"deepseek-v4-flash","model_source":"configured","prompt_version":"v1_2026_05_07","run_ids":[9,17,23]},"bridge":{"a_to_b_predicate":"binds_to","b_to_c_predicate":"associated_with","a_to_b_evidence_count":1,"b_to_c_evidence_count":3,"edge_support_log_ab":0.6931471805599453,"edge_support_log_bc":1.3862943611198906,"novelty_factor":1.0,"direct_a_to_c_count":0},"embedding":{"model":"bge-m3","dim":1024,"max_length":8192,"similarity_scores":{}},"scoring":{"method":"swanson_abc_log_evidence_with_novelty_penalty","formula":"score = min((log(ab+1) + log(bc+1)) * novelty / 10, 1.0); novelty = 1.0 if direct==0 else 0.7 / (direct+1)","score_raw":0.20794415416798356,"score":0.20794415416798356,"quality_tier":"mid","quality_reason":null},"pipeline_run":{"id":4,"run_uuid":"eb8b7730-d92e-4cd5-95dd-95f6c5d62cc2","command":"scripts/backfill_provenance_v2.py:v2_2026_05_12","status":"completed","git_commit":"9996ffaa56e9b7cd5f677bd8203624c2c18aa000","host":"MacBook-Pro-Daniel96.local","started_at":"2026-05-12T21:35:53.363326+00:00","ended_at":"2026-05-12T21:43:41.903387+00:00","notes":"Retroactive provenance backfill on 2026-05-13 for snapshot v2_2026_05_12. Synthetic pipeline_runs row — original generation run records are lost (pre-date provenance schema). All recoverable fields populated from current DB state (claims, works, repurposing_hypotheses); pipeline_run record is synthetic, hence completeness='partial_backfill'.\nBackfilled 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.","domains":["als","alzheimer","depression","epilepsy","glioblastoma","inflammatory_bowel_disease","multiple_sclerosis","pancreatic_cancer","rheumatoid_arthritis","type_2_diabetes"]},"generated_at":"2026-05-12T21:43:39.496175+00:00"}