{"schema_version":"1.0","hypothesis_id":1377,"triple":{"drug":"Si306","drug_canonical":"si306","mediator":"Src","mediator_canonical":"src","outcome":"Vascular dementia","outcome_canonical":"Vascular dementia"},"domain":{"domain":"cross_domain","source":"glioblastoma","target":"alzheimer"},"provenance_completeness":"partial_backfill","completeness_notes":"Backfilled retroactively from DB state on 2026-05-13. The pipeline_run this row references was created by the backfill script, not by the actual generation orchestrator. Source papers, claims, scoring, and embedding config are recovered; generation-time metadata (exact git commit at gen time, host, exact command) is not recoverable.","source_papers":[{"doi":"10.3389/fnagi.2023.1070854","pmid":"36761180","year":2023,"roles":["mediator_outcome"],"title":"Urinary protein biomarkers based on LC–MS/MS analysis to discriminate vascular dementia from Alzheimer’s disease in Han Chinese population","journal":"Front Aging Neurosci","work_id":68245,"publication_date":"2023-01-25"},{"doi":"10.3390/cancers12061570","pmid":"32545852","year":2020,"roles":["drug_mediator"],"title":"Src Inhibitors Pyrazolo[3,4-d]pyrimidines, Si306 and Pro-Si306, Inhibit Focal Adhesion Kinase and Suppress Human Glioblastoma Invasion In Vitro and In Vivo","journal":"Cancers (Basel)","work_id":6170,"publication_date":"2020-06-14"},{"doi":"10.3390/ijms20194745","pmid":"31554327","year":2019,"roles":["drug_mediator"],"title":"Proton Therapy and Src Family Kinase Inhibitor Combined Treatments on U87 Human Glioblastoma Multiforme Cell Line","journal":"Int J Mol Sci","work_id":2268,"publication_date":"2019-09-24"},{"doi":"10.3390/cancers11060848","pmid":"31248184","year":2019,"roles":["drug_mediator"],"title":"A New Strategy for Glioblastoma Treatment: In Vitro and In Vivo Preclinical Characterization of Si306, a Pyrazolo[3,4-d]Pyrimidine Dual Src/P-Glycoprotein Inhibitor","journal":"Cancers (Basel)","work_id":2013,"publication_date":"2019-06-19"}],"source_paper_count":4,"extracted_claims":[{"side":"drug_mediator","object":"Src","context":"preclinical study","subject":"Si306","work_id":2013,"claim_id":2960,"polarity":"positive","predicate":"inhibits","confidence":0.9,"extraction_run_id":7},{"side":"drug_mediator","object":"SRC","context":"in U87 glioblastoma cell line","subject":"Si306","work_id":2268,"claim_id":3081,"polarity":"positive","predicate":"inhibits","confidence":0.9,"extraction_run_id":7},{"side":"drug_mediator","object":"Src","context":"human GBM cell lines","subject":"Si306","work_id":6170,"claim_id":7177,"polarity":"positive","predicate":"inhibits","confidence":0.9,"extraction_run_id":9},{"side":"mediator_outcome","object":"vascular dementia","context":"urine samples from Han Chinese population, compared to Alzheimer's disease","subject":"SRC","work_id":68245,"claim_id":55850,"polarity":"positive","predicate":"predicts","confidence":0.7,"extraction_run_id":16}],"extracted_claim_count":4,"extraction":{"model":"deepseek-v4-flash","model_source":"configured","prompt_version":"v1_2026_05_07","run_ids":[7,9,16]},"bridge":{"a_to_b_predicate":"inhibits","b_to_c_predicate":"predicts","a_to_b_evidence_count":3,"b_to_c_evidence_count":1,"edge_support_log_ab":1.3862943611198906,"edge_support_log_bc":0.6931471805599453,"novelty_factor":1.0,"direct_a_to_c_count":0},"embedding":{"model":"bge-m3","dim":1024,"max_length":8192,"similarity_scores":{}},"scoring":{"method":"swanson_abc_log_evidence_with_novelty_penalty","formula":"score = min((log(ab+1) + log(bc+1)) * novelty / 10, 1.0); novelty = 1.0 if direct==0 else 0.7 / (direct+1)","score_raw":0.20794415416798356,"score":0.20794415416798356,"quality_tier":"mid","quality_reason":null},"pipeline_run":{"id":4,"run_uuid":"eb8b7730-d92e-4cd5-95dd-95f6c5d62cc2","command":"scripts/backfill_provenance_v2.py:v2_2026_05_12","status":"completed","git_commit":"9996ffaa56e9b7cd5f677bd8203624c2c18aa000","host":"MacBook-Pro-Daniel96.local","started_at":"2026-05-12T21:35:53.363326+00:00","ended_at":"2026-05-12T21:43:41.903387+00:00","notes":"Retroactive provenance backfill on 2026-05-13 for snapshot v2_2026_05_12. Synthetic pipeline_runs row — original generation run records are lost (pre-date provenance schema). All recoverable fields populated from current DB state (claims, works, repurposing_hypotheses); pipeline_run record is synthetic, hence completeness='partial_backfill'.\nBackfilled 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.","domains":["als","alzheimer","depression","epilepsy","glioblastoma","inflammatory_bowel_disease","multiple_sclerosis","pancreatic_cancer","rheumatoid_arthritis","type_2_diabetes"]},"generated_at":"2026-05-12T21:43:39.496175+00:00"}