{"schema_version":"1.0","hypothesis_id":1376,"triple":{"drug":"carbon dot probes","drug_canonical":"carbon dot probes","mediator":"GFAP","mediator_canonical":"GFAP","outcome":"cognitive decline","outcome_canonical":"cognitive decline"},"domain":{"domain":"cross_domain","source":"glioblastoma","target":"alzheimer"},"provenance_completeness":"partial_backfill","completeness_notes":"Backfilled retroactively from DB state on 2026-05-13. The pipeline_run this row references was created by the backfill script, not by the actual generation orchestrator. Source papers, claims, scoring, and embedding config are recovered; generation-time metadata (exact git commit at gen time, host, exact command) is not recoverable.","source_papers":[{"doi":"10.1002/alz.70040","pmid":"40110647","year":2025,"roles":["mediator_outcome"],"title":"Exploratory analysis of the proteomic profile in plasma in adults with Down syndrome in the context of Alzheimer's disease","journal":"Alzheimers Dement","work_id":68645,"publication_date":"2025-03-01"},{"doi":"10.1093/brain/awad330","pmid":"37787146","year":2023,"roles":["mediator_outcome"],"title":"Longitudinal associations of serum biomarkers with early cognitive, amyloid and grey matter changes","journal":"Brain","work_id":63087,"publication_date":"2023-10-03"},{"doi":"10.1212/wnl.0000000000201289","pmid":"36446595","year":2022,"roles":["mediator_outcome"],"title":"Longitudinal Changes in Blood Biomarkers of Clinical Alzheimer Disease in a Biracial Population Sample","journal":"Neurology","work_id":65998,"publication_date":"2022-11-30"},{"doi":"10.1039/d2na00060a","pmid":"35434521","year":2022,"roles":["drug_mediator"],"title":"Carbon dot-based fluorescent antibody nanoprobes as brain tumour glioblastoma diagnostics","journal":"Nanoscale Adv","work_id":1302,"publication_date":"2022-01-01"}],"source_paper_count":4,"extracted_claims":[{"side":"drug_mediator","object":"GFAP","context":"in human glioblastoma tissues via antibody conjugation","subject":"carbon dot probes","work_id":1302,"claim_id":1862,"polarity":"positive","predicate":"binds_to","confidence":0.9,"extraction_run_id":7},{"side":"mediator_outcome","object":"cognitive decline","context":"in cognitively unimpaired elderly, memory and language domains","subject":"GFAP","work_id":63087,"claim_id":44224,"polarity":"positive","predicate":"predicts","confidence":0.95,"extraction_run_id":16},{"side":"mediator_outcome","object":"cognitive decline","context":"in a biracial population sample over 17 years","subject":"GFAP","work_id":65998,"claim_id":51085,"polarity":"positive","predicate":"associated_with","confidence":0.95,"extraction_run_id":16},{"side":"mediator_outcome","object":"cognitive decline","context":"in DS with clinical and/or cognitive decline","subject":"GFAP","work_id":68645,"claim_id":56607,"polarity":"positive","predicate":"correlates_with","confidence":0.8,"extraction_run_id":16}],"extracted_claim_count":4,"extraction":{"model":"deepseek-v4-flash","model_source":"configured","prompt_version":"v1_2026_05_07","run_ids":[7,16]},"bridge":{"a_to_b_predicate":"binds_to","b_to_c_predicate":"predicts","a_to_b_evidence_count":1,"b_to_c_evidence_count":3,"edge_support_log_ab":0.6931471805599453,"edge_support_log_bc":1.3862943611198906,"novelty_factor":1.0,"direct_a_to_c_count":0},"embedding":{"model":"bge-m3","dim":1024,"max_length":8192,"similarity_scores":{}},"scoring":{"method":"swanson_abc_log_evidence_with_novelty_penalty","formula":"score = min((log(ab+1) + log(bc+1)) * novelty / 10, 1.0); novelty = 1.0 if direct==0 else 0.7 / (direct+1)","score_raw":0.20794415416798356,"score":0.20794415416798356,"quality_tier":"mid","quality_reason":null},"pipeline_run":{"id":4,"run_uuid":"eb8b7730-d92e-4cd5-95dd-95f6c5d62cc2","command":"scripts/backfill_provenance_v2.py:v2_2026_05_12","status":"completed","git_commit":"9996ffaa56e9b7cd5f677bd8203624c2c18aa000","host":"MacBook-Pro-Daniel96.local","started_at":"2026-05-12T21:35:53.363326+00:00","ended_at":"2026-05-12T21:43:41.903387+00:00","notes":"Retroactive provenance backfill on 2026-05-13 for snapshot v2_2026_05_12. Synthetic pipeline_runs row — original generation run records are lost (pre-date provenance schema). All recoverable fields populated from current DB state (claims, works, repurposing_hypotheses); pipeline_run record is synthetic, hence completeness='partial_backfill'.\nBackfilled 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.","domains":["als","alzheimer","depression","epilepsy","glioblastoma","inflammatory_bowel_disease","multiple_sclerosis","pancreatic_cancer","rheumatoid_arthritis","type_2_diabetes"]},"generated_at":"2026-05-12T21:43:39.496175+00:00"}