{"schema_version":"1.0","hypothesis_id":1165,"triple":{"drug":"G721-0282","drug_canonical":"g721-0282","mediator":"CHI3L1","mediator_canonical":"chi3l1","outcome":"ALS","outcome_canonical":"amyotrophic lateral sclerosis"},"domain":{"domain":"cross_domain","source":"glioblastoma","target":"als"},"provenance_completeness":"partial_backfill","completeness_notes":"Backfilled retroactively from DB state on 2026-05-13. The pipeline_run this row references was created by the backfill script, not by the actual generation orchestrator. Source papers, claims, scoring, and embedding config are recovered; generation-time metadata (exact git commit at gen time, host, exact command) is not recoverable.","source_papers":[{"doi":"10.3390/jcm12062367","pmid":"36983366","year":2023,"roles":["mediator_outcome"],"title":"Plasma CHI3L1 in Amyotrophic Lateral Sclerosis: A Potential Differential Diagnostic Biomarker","journal":"J Clin Med","work_id":54666,"publication_date":"2023-03-19"},{"doi":"10.1016/j.biopha.2023.114520","pmid":"36921538","year":2023,"roles":["drug_mediator"],"title":"Multimodal study of CHI3L1 inhibition and its effect on angiogenesis, migration, immune response and refractive index of cellular structures in glioblastoma","journal":"Biomed Pharmacother","work_id":1340,"publication_date":"2023-03-13"},{"doi":"10.3389/fneur.2021.629332","pmid":"34054686","year":2021,"roles":["mediator_outcome"],"title":"Monocyte-Derived Macrophages Contribute to Chitinase Dysregulation in Amyotrophic Lateral Sclerosis: A Pilot Study","journal":"Front Neurol","work_id":137448,"publication_date":"2021-05-14"},{"doi":"10.1136/jnnp-2019-321916","pmid":"31937582","year":2020,"roles":["mediator_outcome"],"title":"Cross-sectional and longitudinal measures of chitinase proteins in amyotrophic lateral sclerosis and expression of CHI3L1 in activated astrocytes","journal":"J Neurol Neurosurg Psychiatry","work_id":50575,"publication_date":"2020-01-14"}],"source_paper_count":4,"extracted_claims":[{"side":"drug_mediator","object":"CHI3L1","context":"in glioblastoma","subject":"G721-0282","work_id":1340,"claim_id":1924,"polarity":"positive","predicate":"inhibits","confidence":0.95,"extraction_run_id":7},{"side":"mediator_outcome","object":"ALS","context":"CSF, compared to healthy controls","subject":"CHI3L1","work_id":50575,"claim_id":28739,"polarity":"positive","predicate":"associated_with","confidence":0.95,"extraction_run_id":15},{"side":"mediator_outcome","object":"ALS","context":"compared with healthy controls","subject":"CHI3L1","work_id":54666,"claim_id":36244,"polarity":"negative","predicate":"predicts","confidence":0.8,"extraction_run_id":15},{"side":"mediator_outcome","object":"ALS","context":"in monocyte-derived macrophages","subject":"CHI3L1","work_id":137448,"claim_id":100095,"polarity":"positive","predicate":"associated_with","confidence":0.9,"extraction_run_id":21}],"extracted_claim_count":4,"extraction":{"model":"deepseek-v4-flash","model_source":"configured","prompt_version":"v1_2026_05_07","run_ids":[7,15,21]},"bridge":{"a_to_b_predicate":"inhibits","b_to_c_predicate":"associated_with","a_to_b_evidence_count":1,"b_to_c_evidence_count":3,"edge_support_log_ab":0.6931471805599453,"edge_support_log_bc":1.3862943611198906,"novelty_factor":1.0,"direct_a_to_c_count":0},"embedding":{"model":"bge-m3","dim":1024,"max_length":8192,"similarity_scores":{}},"scoring":{"method":"swanson_abc_log_evidence_with_novelty_penalty","formula":"score = min((log(ab+1) + log(bc+1)) * novelty / 10, 1.0); novelty = 1.0 if direct==0 else 0.7 / (direct+1)","score_raw":0.20794415416798356,"score":0.20794415416798356,"quality_tier":"mid","quality_reason":null},"pipeline_run":{"id":4,"run_uuid":"eb8b7730-d92e-4cd5-95dd-95f6c5d62cc2","command":"scripts/backfill_provenance_v2.py:v2_2026_05_12","status":"completed","git_commit":"9996ffaa56e9b7cd5f677bd8203624c2c18aa000","host":"MacBook-Pro-Daniel96.local","started_at":"2026-05-12T21:35:53.363326+00:00","ended_at":"2026-05-12T21:43:41.903387+00:00","notes":"Retroactive provenance backfill on 2026-05-13 for snapshot v2_2026_05_12. Synthetic pipeline_runs row — original generation run records are lost (pre-date provenance schema). All recoverable fields populated from current DB state (claims, works, repurposing_hypotheses); pipeline_run record is synthetic, hence completeness='partial_backfill'.\nBackfilled 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.\nRefreshed 1,618 provenance rows. Source papers: avg=3.73, zero=0. Claims matched: avg=4.09, zero=0.","domains":["als","alzheimer","depression","epilepsy","glioblastoma","inflammatory_bowel_disease","multiple_sclerosis","pancreatic_cancer","rheumatoid_arthritis","type_2_diabetes"]},"generated_at":"2026-05-12T21:43:39.496175+00:00"}